Our team

Investigators from 55 centers in 12 European countries are contributing to the success of the 4C Study. The study is coordinated by regional coordinators that are responsible for regular cardiovascular workups and ensure that the study runs smoothly in their country or region.

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Franz Schaefer

 

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Karolis Azukaitis

 

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Dr. Anke Doyon

Germany

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Dr. Daniela Thurn-Valassina

Germany

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Dr. Rukshana Shroff

United Kingdom

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Dr. Mietek Litwin

Poland

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Dr. Aysun K. Bayazit

Turkey

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Dr. Anette Melk

Germany

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Dr. Ali Duzova

Turkey

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Dr. Nur Canpolat

Turkey

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Dr. Salim Çaliskan

Turkey

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Dr. Mahmut Civilibal

Turkey

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Dr. Sevgi Mir

Turkey

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Dr. Betül Sözeri

Turkey

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Dr. Yelda Bilginer

Turkey

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Uwe Querfeld

Germany

Our story

Adult patients with chronic kidney disease are at much increased risk of dying from cardiovascular events. The risk is most increased in young patients with end-stage renal disease, who are almost as likely to suffer from cardiovascular diseases as elderly individuals in the general population. Early abnormalities of the heart and vessels can be detected even in adolescents with chronic kidney disease, but information about the frequency, severity and natural course of these changes in different stages of kidney failure is lacking. The factors that put young patients with chronic kidney disease at risk of developing early and progressive cardiovascular disease are still elusive.

 

The pediatric population is uniquely suited to study the effects of chronic kidney disease on the heart and vessels due to the absence of lesions related to ageing, diabetes and smoking. In order to improve our understanding of the causes and consequences of early cardiovascular damage in children with progressive chronic kidney disease, a consortium of pediatric nephrologists in Europe has joined to perform a long-term prospective observational study following the heart and vessels of children as they advance through successive stages of chronic kidney disease.

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5

Active patients

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55

Participating centers

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12

European countries

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Study investigators

Our objectives

The 4C Study is following 704 patients aged 6 to 17 years with a glomerular filtration rate of 10 to 60 ml/min/1.73 m² in 55 pediatric nephrology units in 12 European countries.

The structure and function of the heart and the large arteries is regularly tested by sensitive, non-invasive methods and the findings are compared to a large group of healthy children.

Multiple potential clinical, anthropometric, biochemical and medication-related risk factors are monitored prospectively and will be related to the cardiovascular status of the patients.

A genome-wide association study will allow to identify common genetic variants associated with the progression of cardiovascular alterations and renal failure..

Patients are followed on when they enter end-stage kidney disease. The effects of dialysis and transplantation on  cardiovascular health are addressed in separate sub-studies (4C-D, 4C-T).

Effects of kidney failure in childhood on the fine structure of artery and other tissues will be investigated in biopsy studies (4C-A, 4C-P).

Long-term renal and cardiovascular burden and outcomes will be assessed in a self-reported online survey based 4C-TRACK study.

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